Table 4. SARS-CoV-2 RT-PCR mean cycle threshold value change from baseline to day five, day 10, and day 14.
SD = standard deviation; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; RT-PCR = reverse transcription polymerase chain reaction; mITT = modified intent-to-treat; PP = protocol population; EOT = end of treatment
| Visit | Molnupiravir (N = 608), mean (change from baseline ± SD) | Standard of care (N = 610), mean (change from baseline ± SD) | Molnupiravir versus standard of care (p-value**) | Molnupiravir (N = 593), mean (change from baseline ± SD) | Standard of care (N = 581), mean (change from baseline ± SD) | Molnupiravir versus standard of care (p-value**) |
| mITT population | PP population | |||||
| Baseline | 25.9 (3.8) | 25.9 (3.8) | 25.8 (3.8) | 25.8 (3.9) | ||
| Day 5 (EOT) | 35.4 (9.5 ± 5.2) | 31.2 (5.3 ± 4.9) | <0.0001 | 35.7 (9.9 ± 4.9) | 31.4 (5.6 ± 4.8) | <0.0001 |
| Day 10 | 35.5 (9.7 ± 6.4) | 31.9 (6.1 ± 7.7) | <0.0001 | 35.8 (10.0 ± 6.2) | 32.2 (6.4 ± 7.7) | <0.0001 |
| Day 14 | 35.4 (9.5 ± 7.0) | 30.7 (4.9 ± 10.6) | <0.0001 | 35.6 (9.8 ± 6.9) | 30.8 (5.0 ± 10.9) | <0.0001 |