Fig. 1.

Overview of the Notch and Hedgehog signaling pathways. The blue arrows on the left side of the figure demonstrate the synthesis, modification, transfer and activation of Notch receptor precursors. The purple arrow on the right shows Hh ligand precursor synthesis, modification and translocation, and activation effect of Hh receptors. Crosstalk in the Hh and Notch signaling pathways is shown by red and yellow arrows