Table 2.

[¹¹C]EKAP BP across all ROIs in cocaine-naïve socially housed female and male monkeys (N = 8/sex).

	Females				Males				Interaction
	Dominant	Subordinate	post-hocb		Dominant	Subordinate	post-hocb		Sex and Social Rank
ROI	Mean (SD)		F	Pr  > F	Mean (SD)		F	Pr > F	t-Valuea	Pr > |t|a
Dorsal PFC	0.46 (0.25)	1.14 (0.45)	13.9	0.01	0.69 (0.06)	0.68 (0.05)	0.01	0.93	−2.70	0.02
Medial PFC	0.77 (0.22)	1.10 (0.24)	6.42	0.052	0.82 (0.17)	0.84 (0.06)	0.01	0.91	−1.71	0.11
Orbito FC	0.75 (0.28)	1.08 (0.16)	6.51	0.051	0.93 (0.11)	1.03 (0.13)	0.56	0.47	−1.27	0.23
Anterior Cing Cortex	0.85 (0.20)	1.62 (0.30)	17.4	0.003	1.02 (0.35)	1.19 (0.14)	0.82	0.38	−2.31	0.04
Caudate	0.82 (0.21)	1.34 (0.30)	10.7	0.01	1.40 (0.19)	1.24 (0.18)	1.08	0.32	−3.05	0.01
Putamen	0.94 (0.15)	1.58 (0.40)	17.2	0.003	1.45 (0.04)	1.30 (0.11)	0.93	0.36	−3.61	0.004
Ventral Striatum	0.83 (0.07)	1.25 (0.27)	17.2	0.003	1.27 (0.07)	1.12 (0.02)	2.26	0.16	−4.00	0.002
Amygdala	0.84 (0.12)	1.33 (0.42)	7.54	0.04	1.21 (0.14)	1.02 (0.22)	1.13	0.31	−2.70	0.02
Globus Pallidus	0.78 (0.06)	1.27 (0.41)	10.8	0.01	1.31 (0.07)	1.01 (0.10)	3.87	0.07	−3.72	0.003
Insula	0.92 (0.15)	1.71 (0.37)	26.5	0.0005	1.52 (0.13)	1.26 (0.10)	2.79	0.12	−4.82	0.0004
Claustrum	1.03 (0.14)	1.85 (0.49)	19.4	0.002	1.57 (0.09)	1.41 (0.12)	0.74	0.41	−3.72	0.003
Cingulate Cortex	0.73 (0.14)	1.33 (0.13)	33.9	0.0002	1.22 (0.11)	1.19 (0.18)	0.08	0.78	−4.32	0.001
Hippocampus	0.79 (0.10)	1.30 (0.48)	7.86	0.03	1.05 (0.10)	0.77 (0.12)	2.35	0.15	−3.07	0.01
Thalamus	0.67 (0.30)	0.87 (0.23)	1.54	0.29	1.15 (0.21)	0.89 (0.20)	2.41	0.29	−1.98	0.07
Temporal Cortex	0.39 (0.04)	0.78 (0.34)	6.95	0.04	0.93 (0.14)	0.70 (0.21)	2.38	0.15	−2.95	0.01
Cerebellum	0.03 (0.02)	0.05 (0.03)	−	−	0.03 (0.05)	0.04 (0.06)	−	−	−	−

^aTwo-way ANOVA was used to compare [¹¹C]EKAP BP for each ROI by sex and social rank.

^bPost-hoc F-test with Bonferroni-Holm adjustment was used to determine social rank differences by sex. Bold values represent statistical significance.