FIG. 3.

Brain histopathology of mice receiving 3 × 10⁸ CFU i.v. (A) At 1 month after inoculation, one nonnecrotizing granuloma was seen; HE strain. (B) Perivascular cuffing seen 2 months after inoculation. HE stain. (C) mild choroid plexus infiltration. HE stain. (D) acid-fast bacilli in the parenchyma of the choroid plexus. AFB stain. (E and F) At 4 months after infection there was cellular infiltration along the ventricle (E) (HE stain) and acid-fast bacilli were found in the lesion (F) (AFB stain). (G and H) At 6 months after inoculation, meningeal granuloma with foamy histiocytes was found (G) (HE stain) containing numerous acid-fast bacilli (H) (AFB stain). Magnifications: A and C, ×100; B, ×400; D, ×630; E and G, ×250; F and H, ×600.