TABLE 1.
Bacterial load in blood and brain after infection by different routes
| Time postinfection | Sample | Mean no. of bacteriaa (log CFU) (n = 3)
|
|||
|---|---|---|---|---|---|
| 107 CFU i.v. | 108 CFU i.v. | 109 CFU i.v. | 104 CFU i.c. | ||
| 2 h | Blood | 4.88 | 5.47 | >6.24 | |
| Brain | 0 | 0 | 0 | 2.13 | |
| 1 day | Blood | 3.80 | 4.78 | 4.58 | |
| Brain | 2.88 | 3.27 | 2.95 | 2.78 | |
| 7 days | Blood | 4.62 | 3.38 | 4.32 | |
| Brain | 3.151 | 3.88 | 4.01 | 3.381 | |
| 14 days | Blood | 2.56 | 2.65 | 4.88 | |
| Brain | 4.301,2 | 3.951 | 4.181 | 4.011,2 | |
| 28 days | Blood | <1.8 | 4.34 | 5.30 | |
| Brain | 3.651 | 4.561,2,3 | 4.691,2 | 4.511,2 | |
| 56 days | Blood | 2.36 | 4.04 | 3.71 | |
| Brain | 2.87 | 4.681,2,3 | 4.691,2 | 3.40 | |
a
1, P < 0.05 compared with the number of bacteria in the brain at day 1; 2, P < 0.05 compared with the number of bacteria in the brain at day 7; 3, P < 0.05 compared with the number of bacteria in the brain at day 14.