TABLE 3.

Bivariate correlation between age and each concentration level in DS and control groups excluding strong outliers.

	DS					Control
	THF	5-methyl-THF	5-formyl-THF	SAH	SAM	THF	5-methyl-THF	5-formyl-THF	SAH	SAM
r	0.089	-0.085	0.128	0.152	0.099	0.395	0.271	0.239	0.102	0.115
p-value	0.362	0.318	0.261	0.145	0.644	0.011*	0.121	0.296	0.678	0.682

The table reports for each metabolite the results of the statistical analyses in DS and control groups indicated by Pearson correlation coefficient (r) and two-tailed significance (p-value). Significant r (>0.4) and p-values (<0.05) are marked with an “*”. The detailed results of bivariate correlation with and without strong outliers are shown in Supplementary Table 8.