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. 2022 Dec 1;13:1064661. doi: 10.3389/fphar.2022.1064661

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Copyright © 2022 Luo, Jiang, Anfu Zheng, Zhao, Wu, Li, Du, Chen, Deng, Chen, Li, Li, Gu, Sun, Xiao and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HIF-1α-mediated stemness and drug resistance. On the one hand, HIF-1α can induce drug resistance by regulating stem cell surface markers. On the other hand, HIF-1α promotes chemotherapy resistance through drug resistance-related proteins.