Table 3.
Markers of cell damage, neutrophil and macrophage activation in COVID-19 patients with and without detectable SARS-CoV-2 RNAemia (Mann-Whitney independent samples test)
| Total | SARS-CoV-2 RNAemia (negative plasma samples, n=126) |
SARS-CoV-2 RNAemia (positive plasma samples, n=30) |
p-value | |
|---|---|---|---|---|
| Alu 115 (n-cfDNA) pg/μla, median(IQR) | 361.67 (154.23-1041.85) | 318.68 (145.52-904.82) | 801.60 (382.90-1479.74) | 0.005 |
| Alu 247 (n-cfDNA) pg/μla, median(IQR) | 136.86 (52.62-519.81) | 113.15 (46.52-417.98) | 296.05 (74.86-931.76) | 0.055 |
| Alu 247/115 (n-cfDNA integrity), median(IQR) | 0.44 (0.27-0.69) | 0.46 (0.28-0.68) | 0.32 (0.23-0.73) | 0.380 |
| MT-CO3 (mt-cfDNA ) pg/μlb, median(IQR) | 2.380 (1.12-5.22) | 1.985 (0.98-4.65) | 4.26 (2.01-8.26) | 0.002 |
| NE ng/ml , median(IQR) | 105.1 (56.50-172.95) | 93.95 (48.60-154.50) | 154.00 (100.20-234.00) | <0.001 |
| LL-37 ng/mL, median(IQR) | 39.0 (26.8-55.6) | 39.3 (27.4-58.0) | 34.05 (24.9-48.8) | 0.501 |
| sCD163, median(IQR) | 647.60 (441.00-951.9000) | 644.00 (375.00-940.45) | 676.00 (541.80-1161.50) | 0.149 |
aAbsolute equivalent amount of genomic DNA/μl in the extracted sample. bAbsolute equivalent amount of the template (mitochondrial) DNA in the extracted sample. Font in bold: significant p-value