Table 4.
Cox proportional hazard ratios (HR) for survival based on different multivariate models
| Multivariate model (1) |
Multivariate model (2) |
Multivariate model (3) |
||||
|---|---|---|---|---|---|---|
| HR (95%CI) | p-value | HR (95%CI) | p-value | HR (95%CI) | p-value | |
| n-cfDNA integrity tertiles | ||||||
| 3 (Alu247/115 > 0.625) | 1 | 1 | 1 | |||
| 2 (0.321 < Alu247/115 ≤ 0.625) | 1.55 (0.64-3.77) | 0.332 | 1.56 (0.64-3.79) | 0.328 | 1.72 (0.70-4.24) | 0.241 |
| 1 (Alu247/115 < 0.321) | 3.74 (1.61-8.74) | 0.002 | 4.79 (2.00-11.48) | <0.001 | 4.14 (1.71-10.02) | 0.002 |
| Neutrophil elastase tertiles | ||||||
| 1 (NE ≤ 74.0) | 1 | 1 | 1 | |||
| 2 (74 < NE ≤ 146.7) | 0.87 (0.39-1.96) | 0.734 | 1.47 (0.61-3.50) | 0.390 | 1.27 (0.52-3.11) | 0.594 |
| 3 (NE > 146.7) | 1.77 (0.78-3.99) | 0.171 | 3.88 (1.53-9.86) | 0.004 | 2.94 (1.10-7.89) | 0.032 |
| sCD163 tertiles | ||||||
| 1 (sCD163 ≤ 491) | 1 | 1 | 1 | |||
| 2 (491 < sCD163 ≤ 811) | 3.06 (1.32-7.10) | 0.009 | 2.78 (1.15-6.72) | 0.023 | 2.60 (1.09-6.24) | 0.032 |
| 3 (sCD163 > 811) | 2.34 (0.99-5.50) | 0.052 | 2.40 (0.98-5.89) | 0.056 | 2.25 (0.91-5.52) | 0.078 |
| Sex | ||||||
| Male | 1 | 1 | 1 | |||
| Female | 1.11 (0.60-2.03) | 0.739 | 1.20 (0.63-2.28) | 0.587 | 1.17 (0.61-2.23) | 0.637 |
| Age | 1.10 (1.04-1.16) | 0.001 | 1.09 (1.03-1.15) | 0.004 | 1.08 (1.02-1.15) | 0.008 |
| Stroke | ||||||
| No | 1 | 1 | ||||
| Yes | 1.51 (0.66-3.44) | 0.329 | 1.44 (0.62-3.34) | 0.398 | ||
| COPD | ||||||
| No | 1 | 1 | ||||
| Yes | 4.76 (2.07-10.94) | <0.001 | 4.47 (1.90-10.48) | 0.001 | ||
| CKD | ||||||
| No | 1 | 1 | ||||
| Yes | 0.89 (0.44-1.81) | 0.745 | 0.85 (0.41-1.74) | 0.656 | ||
| CFS | ||||||
| Ref. Cat. (0-3) | 1 | 1 | ||||
| 1 (4-7) | 4.92 (1.10-22.01) | 0.037 | 4.63 (1.04-20.65) | 0.044 | ||
| 2 (8-9) | 4.53 (0.98-20.93) | 0.053 | 4.32 (0.94-19.77) | 0.059 | ||
| SARS-CoV-2 RNAemia | ||||||
| Negative | 1 | |||||
| Positive | 1.91 (1.00-3.65) | 0.051 | ||||
Font in bold: significant p-value