Table 1.
Characteristics of the study population
| Characteristic | All recipients | Rejection | No rejection | P valuea |
|---|---|---|---|---|
| Age (median, range) | 57 (18–79) | 56 (21–77) | 57 (18–79) | 0.258c |
| Sex, n (%) | 0.394d | |||
| Male | 703 (69) | 142 (71) | 561 (68) | |
| Female | 322 (31) | 58 (29) | 265 (32) | |
| Rejection, n (%) | 199 (19) | 199 (100) | ||
| T cell-mediated, n (%) | 178 (17) | 178 (89) | ||
| Antibody-mediated, n (%) | 21 (3) | 21 (11) | ||
| Primary diagnosis, n (%) | ||||
| Polycystic kidney disease | 202 (20) | 42 (21) | 160 (19) | |
| Diabetic nephropathy with type I diabetes | 150 (15) | 31 (16) | 119 (14) | |
| IgA nephropathy | 106 (10) | 18 (9) | 88 (11) | |
| Chronic kidney disease, unspecified | 105 (10) | 21 (11) | 84 (10) | |
| Diabetic nephropathy with type II diabetes | 84 (8) | 16 (8) | 68 (8) | |
| Other | 378 (37) | 71 (35) | 307 (38) | |
| Median (IQR) | ||||
| Follow-up time, mo | 37 (18–63) | 35 (16–59) | 38 (18–63) | 0.087c |
| PRA I > 0, %b | 22 (5–55) | 17 (2–58) | 23 (5–54) | 0.353c |
| PRA II > 0, %b | 27 (12–60) | 45 (17–77) | 26 (12–50) | 0.074c |
| Cold ischemia, h | 20 (17–23) | 20 (17–23) | 20 (17–23) | 0.300e |
| HLA eplet mismatch sum, n | 27 (19–36) | 31 (23–39) | 26 (18–35) | <0.001c |
| HLA I eplet mismatch sum, n | 11 (7–15) | 12 (8–16) | 11 (7–15) | 0.031c |
| HLA II eplet mismatch sum, n | 16 (7–24) | 19 (12–27) | 15 (6–23) | <0.001c |
HLA, human leukocyte antigen; IgA, Immunoglobulin A; IQR, interquartile range; PRA, panel-reactive antibody.
a
The significance of variation was calculated between rejection-group and nonrejection-group.
b
The medians of PRA values are calculated only from patients with PRAI > 0 and PRAII > 0
c
The Mann–Whitney U-test.
d
The Pearson chi-square test
e
The t-test