Table 2.

Association between IRRT modality as a time-varying exposure and mortality within 90 days

Variable	Univariable (HR, [95% CI])	P-value	Multivariable (aHR, [95% CI])	P-value
Conventional hemodialysisOnline hemodiafiltration	Ref 0.93 (0.48; 1.78)	0.82	Ref 0.85 (0.43; 1.67)	0.64
Age	1.03 (1.00–1.05)	0.050	1.04 (1.00; 1.08)	0.06
Female sex	1.19 (0.67; 2.11)	0.56	2.28 (1.08; 4.84)	0.032
Charlson comorbitiy score	1.13 (1.00–1.27)	0.052	1.11 (0.93; 1.33)	0.24
Baseline eGFR	1.00 (0.99; 1.01)	0.76	1.01 (1.00; 1.02)	0.045
Initially started on CRRT	0.83 (0.50; 1.38)	0.47	0.53 (0.26; 1.09)	0.08
SOFA score at IRRT initiation	1.08 (1.00–1.16)	0.051	1.14 (1.04; 1.25)	0.007
Admission diagnostic		0.22		0.06
Surgical	Ref		Ref
Medical	1.62 (0.75; 3.49)		2.35 (0.984; 5.636)
Associated clinical conditions
Sepsis	1.40 (0.80; 2.45)	0.25	1.11 (0.54; 2.29)	0.78
Heart failure	0.57 (0.25; 1.32)	0.19	0.33 (0.09; 1.17)	0.09
Both	0.70 (0.21; 2.29)	0.55	0.23 (0.03; 1.83)	0.16

aHR, adjusted hazard ratio; CI, confidence interval; CRRT, continuous renal replacement; eGFR, estimated glomerular filtration rate; HR, hazard ratio; IRRT, intermittent renal replacement therapy; SOFA, Sequential Organ Failure Assessment.

Cox regression model for count processes with HDF exposure as a time-varying covariate. One patient was excluded from the analysis for loss to follow-up after a single IRRT session (N = 181).