Table 3.
Associations between gene expression and stage group and OS in MOC.
| Mean expression by stage group | Univariate | Multivariable | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene | I/II (n = 189) | III/IV (n = 36) | P | n | HR (95% CI) | P | n | HR (95% CI) | P |
| THBS2 | 2.49 | 3.29 | 0.009 | 179 | 1.42 (1.21–1.68) | 2.91E-05 | 179 | 1.25 (1.04–1.51) | 0.016 |
| TAGLN | 1.93 | 2.59 | 0.034 | 179 | 1.36 (1.16–1.58) | 9.87E-05 | 179 | 1.21 (1.01–1.45) | 0.043 |
| DCN | 1.7 | 2.16 | 0.168 | 179 | 1.24 (1.07–1.44) | 0.005 | 179 | 1.05 (0.88–1.26) | 0.584 |
| PLA2R1 | −1.96 | −1.69 | 0.208 | 179 | 1.33 (1.06–1.67) | 0.015 | 179 | 1.28 (0.97–1.69) | 0.082 |
| ERBB2 | 1.18 | −0.06 | 0.003 | 233 | 0.87 (0.78–0.98) | 0.019 | 224 | 0.99 (0.87–1.13) | 0.921 |
| ANXA10 | −1.28 | −2.38 | 0.034 | 233 | 0.95 (0.89–1.01) | 0.107 | |||
| SATB2 | −0.28 | 0.22 | 0.007 | 233 | 1.12 (0.89–1.40) | 0.34 | |||
| PD-L1 (CD274) | −1.23 | −1.06 | 0.627 | 233 | 1.07 (0.93–1.24) | 0.341 | |||
| CK20 (KRT20) | −0.45 | −1.31 | 0.019 | 233 | 1.03 (0.97–1.10) | 0.354 | |||
| VSIG1 | −0.13 | −0.84 | 0.329 | 233 | 0.97 (0.91–1.04) | 0.455 | |||
| MUC2 | 1.3 | 1.17 | 0.829 | 233 | 1.03 (0.95–0.46) | 0.458 | |||
| PGC | 0.13 | 0.36 | 0.782 | 233 | 0.98 (0.93–1.03) | 0.5 | |||
| MUC16 | −2.78 | −1.77 | 0.130 | 233 | 1.02 (0.96–1.08) | 0.567 | |||
| CLDN18 | −1.79 | −2.24 | 0.403 | 233 | 0.98 (0.92–1.05) | 0.649 | |||
| MEP1A | 0.07 | −0.05 | 0.851 | 233 | 0.98 (0.91–1.06) | 0.69 | |||
| GKN1 | −0.06 | 0.06 | 0.294 | 233 | 1.07 (0.73–1.57) | 0.721 | |||
| TYMS | 0.1 | 0.02 | 0.658 | 233 | 1.04 (0.81–1.34) | 0.746 | |||
| MUC5AC | 0.44 | −0.07 | 0.461 | 233 | 1.00 (0.94–1.07) | 0.941 | |||
| PD-1 (PDCD1) | −1.25 | −0.82 | 0.138 | 233 | 1.01 (0.86–1.17) | 0.943 | |||
Note: Difference in expression between stage groups Student t test; HR, hazard ratio, 95% confidence interval; multivariable analysis adjusted for age and stage, stratified by study site.