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. 2022 Dec 1;9:1051418. doi: 10.3389/fnut.2022.1051418

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Copyright © 2022 Elisia, Yeung, Kowalski, Wong, Rafiei, Dyer, Atkar-Khattra, Lam and Krystal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Omega 3 supplements significantly lower PGE₂ levels. (A) Individual PGE₂ levels of the participants on omega 3 supplements for 6 months as determined by PGE₂ competitive ELISAs. (B) Average plasma PGE₂ levels over time from participants taking omega 3 supplements for 6 months (left panel) and from the control group (right panel) over 6 months. All average values shown are the mean ± SEM. (C) Percent change in PGE₂ levels after 6 months on omega 3 supplements, relative to baseline levels. (D) Correlation between EPA and DHA (μg/mL) levels in RBC membranes and PGE₂ levels of participants consuming omega 3 supplements for 6 months. *Denotes significant (P < 0.05) difference when compared to baseline values.