Table 5.

Invasive carcinomas with mixed morphologic features

	Tumor cells in single files and targetoid pattern	Tubules	Note
Mixed IBC-NST and ILC	E-cadherin negative	E-cadherin positive	Despite different morphology and immunoprofile, both components should be measured as a single tumor for staging purposes
Tubulolobular carcinoma	E-cadherin positive	E-cadherin positive	Some pathologists consider this tumor a variant of tubular carcinoma or IBC-NST while others diagnosed them as a variant of ILC
ILC “with tubular elements”	E-cadherin negative	E-cadherin negative	Tubules are β-catenin and P-cadherin positive
IBC-NST “with lobular growth pattern”	E-cadherin positive	E-cadherin positive	Similar cytomorphology throughout the tumor