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. 2022 Sep 1;8(2):veac082. doi: 10.1093/ve/veac082

Figure 9.

Figure 9.

Comparison of RdRp detection from unicellular eukaryote transcriptomes using RdRp-scan HMM profiles versus InterProScan. Data sets obtained from MMETSP transcriptomes (Charon, Murray, and Holmes 2021) were submitted to HMMer3 using either RdRp-scan or InterProScan profiles. False positives are indicated in light red and refer to sequences without RdRp A, B, and C motifs detected and/or detected as non-RdRp in Phyre2 with a confidence score higher than 90 per cent. False negatives are indicated in dark red and refer to previously detected viruses (Charon, Murray, and Holmes 2021) detected using InterProScan or RdRp-scan profiles. True positives are indicated in dark blue and refer to both previously detected viruses (Charon, Murray, and Holmes 2021), and true RdRp-like hits originally discovered using RdRp-scan and InterProScan profiles. True negatives are indicated in light blue and refer to false-positive hits detected using one method but not detected using the other method.