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. Author manuscript; available in PMC: 2023 Dec 31.
Published in final edited form as: Biochem Biophys Res Commun. 2022 Nov 13;637:170–180. doi: 10.1016/j.bbrc.2022.11.014

Figure 2. Deletion of cardiomyocyte SIRT1 attenuated cardiac remodeling induced by pressure overload.

Figure 2.

(A) Upper: Representative hearts from Sirt1f/f and icSirt1−/− under sham operations (Sham) or 6 weeks of TAC surgery-induced pressure overload (TAC). Middle: Representative images of perivascular and interstitial fibrosis measured by Masson’s trichrome staining. The scale bars are 50 μm. Lower: Quantification analysis of Masson’s trichrome staining. Biological replicates N=5 for each group. P value was determined by two-way ANOVA with Tukey’s post-hoc test. (B) Quantitation for real time RT-PCR for mRNA expression of collagen type 1 alpha 1 chain (Col1α1), fibronectin (Fn1), and connective tissue growth factor (Ctgf) in LV tissue. Biological replicates N=8 for each group. P value was determined by two-way ANOVA with Tukey’s post-hoc test.