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. 2022 Sep 6;8(2):veac085. doi: 10.1093/ve/veac085

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — The MSA hierarchy in Flavivirid-GLUE. The GLUE software framework defines a ‘constrained alignment tree’ data structure comprising a set of alignments that are hierarchically linked to reflect taxonomic relationships (Singer et al. 2018). To enable sequence comparisons across the entire Flaviviridae, we implemented a constrained alignment tree data structure in Flavivirid-GLUE, as shown in the cladogram. Numbers shown adjacent to nodes correspond to rows in Table 1. Jingmen, Jingmen tick virus; MBFV, mosquito-borne flavivirus.