TABLE 1.
Marine-derived agents associated with ncRNAs in tumor fundamental cellular processes.
| Marine-derived agents (source) | Related ncRNAs | ncRNA expression regulated by agents | ncRNA roles in tumor | Related cellular processes | Related genes | Tumor types | References |
|---|---|---|---|---|---|---|---|
| miRNA-related marine-derived agents | |||||||
| SZ-685C (Angrove endophytic fungus) | miR-200c | Down-regulated | Oncogene | Inhibition of cell proliferation, induction of apoptosis | PTEN, p-AKT, FOXO1, FOXO3a | Pituitary tumor | Xie et al., (2010); Chen et al., (2013a); Liao et al., (2013) |
| Eribulin (Halichondria okadai) | miR-195 | Up-regulated | Suppressor | Induction of apoptosis | Wnt3a, β-catenin | Breast cancer | Green et al., (2013); Furuya et al., (2016); Yu et al., (2018a) |
| Maritoclax (Streptomyces) | miR-708 | Up-regulated | Suppressor | Induction of apoptosis | cFLIP, TRAIL, CHOP, DR5 | Renal carcinoma | Jeon et al., (2018); Sun et al., (2019) |
| Trabectedin (Ecteinascidia turbinata) | miR-4284, miR-1207-5, miR-1225-5p | Up-regulated | Suppressor | Induction of apoptosis, inhibition of cell migration and motility | SYK, LGALS1 | Biliary tract cancer | Peraldo Neia et al. (2016) |
| pri-miR-17-92, miR-17, miR-20a | Up-regulated | Suppressor | Induction of apoptosis, cell cycle arrest, cellular stress, and DNA damage | IRF4, IKZF1, MICA, MICB, ULBP1, NKG2D | Multiple myeloma | Cuce et al. (2019) | |
| Spirulina (Cyanobacteria) | miR-34a, miR-125b | Up-regulated | Suppressor | Inhibition of cell proliferation | PI3K, AKT, mTOR | Glioma | Arab et al., (2021); Braune et al., (2021) |
| Bostrycin (Alternaria eichhorniae) | miR-638, miR-923 | Up-regulated | Suppressor | Inhibition of cell proliferation | PT3K, AKT, p27 | Lung cancer | Chen et al., (2011); Chen et al., (2012a) |
| Cytarabine (Cryptotethia crypta) | miR-155 | Up-regulated | Suppressor | Inhibition of cell proliferation, induction of cell differentiation and apoptosis | cMYC, cJUN, GFI1, JARID2, MEIS1, TRIB2 | Acute myeloid leukemia | Palma et al. (2014) |
| Fucoidan (Brown seaweed) | miR-29, miR-143 | Up-regulated | Suppressor | Inhibition of cell survival, proliferation, invasive, and EMT process | DNMT3B, MTSS1, NF-κB pathway | Hepatocellular carcinoma | Yan et al., (2015); Zheng et al., (2018); El-Far et al., (2021) |
| 1386A (Mangrove fungus) | let-7a, miR-15/16 | Up-regulated | Suppressor | ND | ND | Breast cancer | Tang et al. (2012) |
| miR-21, miR-27a, miR-633 | Down-regulated | Oncogene | ND | ND | Breast cancer | Tang et al. (2012) | |
| Actinomycin X2 (Streptomyces) | miR-144 | Up-regulated | Oncogene | Inhibition of cell proliferation, induction of apoptosis | PTEN, PI3K, AKT, mTOR | Prostate cancer | Liu et al. (2016) |
| lncRNA-related marine-derived agentsH | |||||||
| Fucoidan (Brown seaweed) | LINC00261 | Up-regualted | Suppressor | Inhibition of cell proliferation and invasion | miR-522-3p, SFRP2 | Hepatocellular carcinoma | Ma et al. (2021) |
| lncRNA-p21 | Up-regualted | Suppressor | Inhibition of cell invasion and metastasis | ND | Hepatocellular carcinoma | Yan et al. (2019) | |
| lncRNA-Saf | Down-regualted | Oncogene | Induction of apoptosis | Fas | Hepatocellular carcinoma | Yan et al., (2005); Yan et al., (2019) | |
| 1-hydroxy-1-Norresistomycin (Streptomyces) | LED, LOC285194 | Up-regualted | Suppressor | Inhibition of cell proliferation, invasion, and metastasis, induction of apoptosis and cell cycle arrest | p53, p21 | Lung cancer | Ramalingam et al. (2018) |
| ASP-3 (Arca subcrenata) | ATG9B | Down-regualted | Oncogene | Inhibition of invasion and metastasis | VEGFR2 | Hepatocellular carcinoma | Guo et al. (2019) |
ND, not determined.