Table 1.

Comparison of NAFLD Pathophysiology mechanisms between in T1D and T2D.

NAFLD pathophysiological mechanisms	T1D	T2D
Insulin resistance	+	+++
Altered dynamic of insulin delivery	++	–
Altered insulin clearance	+++	+
Relative insulin resistance in hepatocytes	++	+++
SREBP and ChREBP activation by hyperglycemic state and high fructose intake	+	++
Hyperglucagonemia and hepatic glucagon resistance (worsened by amylin deficiency)	+++	–
Low GLP-1 blood concentration	+	++

(-: unlikely; +: not unlikely; ++: likely; +++: very likely). T1D, type 1 diabetes; T2D, type 2 diabetes; SREBP, sterol regulatory element-binding proteins; ChREBP, carbohydrate response element-binding protein; GLP-1, glucagon-like peptide-1.