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. 2022 Dec 1;12:917707. doi: 10.3389/fonc.2022.917707

Table 4.

The most globally cited articles on resistance to CDK4/6 inhibitors.

Title First Author Year Journal Local Citations (LC) Global Citations (GC) LC/GC ratio Normalized Global Citations*
The Pezcoller lecture: Cancer cell cycles revisited Sherr, Charles J. 2000 Cancer Research 7 1074 0.65% 7.01
Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial Massimo Cristofanilli 2016 Lancet Oncology 211 919 22.96% 13.82
PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro Richard S Finn 2009 Breast Cancer Research 256 885 28.93% 7.47
Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer Hortobagyi GN 2016 The New England Journal of Medicine 182 821 22.17% 12.35
Treating cancer with selective CDK4/6 inhibitors O’Leary B 2016 Nature Reviews Clinical Oncology 128 557 22.98% 8.38
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade Livnat Jerby-Arnon 2018 Cell 18 430 4.19% 12.26
An F876L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV3100 (Enzalutamide) Korpal M 2013 Cancer Discovery 5 384 1.30% 7.88
Cyclin-dependent kinases regulate the antiproliferative function of Smads Matsuura I 2004 Nature 13 379 3.43% 5.26
AKT/PKB Phosphorylation of p21Cip/WAF1 Enhances Protein Stability of p21Cip/WAF1 and Promotes Cell Survival Li Y 2002 Journal of Biological Chemistry 1 361 0.28% 3.86
Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor–Positive Breast Cancer Herrera-Abreu MT 2016 Cancer Research 216 336 64.29% 5.05

* Normalized Global Citations: Total citations of the article/average citations of peer articles when compared to peer papers (papers published in the same year, in the same discipline, and also in the same literature type).