Table 6.
Factors associated with virologic response in logistic regression model in studied hepatitis C virus-genotype 1b population
|
Effect
|
Effect measure
|
Wald stat
|
OR
|
-95%CI of OR
|
+95%CI of OR
|
P
value
|
| Intercept | 10.742 | 24.208 | 3.600 | 162.775 | 0.001 | |
| Sex | Female | 10.075 | 1.668 | 1.216 | 2.289 | 0.002 |
| HIV-coinfection | Yes | 9.278 | 0.393 | 0.216 | 0.717 | 0.002 |
| Platelets × 1000/μL | Per 1 U increase | 7.619 | 1.004 | 1.001 | 1.006 | 0.006 |
| Decompensation at baseline | No | 4.359 | 2.423 | 1.056 | 5.559 | 0.037 |
| HCC | Yes | 3.733 | 0.459 | 0.208 | 1.011 | 0.053 |
| BMI kg/m2 | Per 1 U increase | 3.154 | 0.971 | 0.940 | 1.003 | 0.076 |
| Treatment-experience | No | 0.972 | 1.180 | 0.849 | 1.639 | 0.324 |
| Albumins g/dL | Per 1 U increase | 0.822 | 1.027 | 0.970 | 1.088 | 0.365 |
| Bilirubin mg/dL | Per 1 U increase | 0.294 | 0.963 | 0.839 | 1.104 | 0.588 |
| Fibrosis | 1 | 0.020 | 0.902 | 0.217 | 3.749 | 0.888 |
| Fibrosis | 2 | 0.255 | 0.690 | 0.164 | 2.911 | 0.614 |
| Fibrosis | 3 | 0.054 | 0.840 | 0.194 | 3.639 | 0.816 |
| Fibrosis | 4 | 0.547 | 0.580 | 0.137 | 2.460 | 0.460 |
| ALT IU/mL | Per 1 U increase | 0.053 | 1.000 | 0.998 | 1.002 | 0.818 |
| History of decompensation | No | 0.010 | 1.039 | 0.500 | 2.160 | 0.918 |
ALT: Alanine transaminase; BMI: Body mass index; CI: Confidence interval; GT: Genotype; HCC: Hepatocellular carcinoma; HCV: Hepatitis C virus; HIV: Human immunodeficiency virus; M: Male; OR: Odds ratio.