Skip to main content
. 2022 Dec 15;14(1):e12365. doi: 10.1002/dad2.12365

FIGURE 2.

FIGURE 2

TDP‐43 is elevated in ADEVs extracted from subjects with an autopsy‐confirmed diagnosis of LATE. Plasma concentrations of TDP‐43 were detected in NDEVs, ADEVs, and MDEVs (A‐F) and in EV depleted plasma (G,H) as measured by our in‐house ELISA and Cusabio kit. NDEV concentrations TDP‐43 was not significantly different between LATE‐NC (+) and LATE‐NC (–) subjects (A,D). ADE concentrations of TDP‐43 were significantly increased in LATE‐NC (+) as compared to LATE‐NC (–) subjects (B,E). MDEV concentrations of TDP‐43 were significantly increased in LATE ‐ NC (+), as measured by our in‐house ELISA (C), while MDE concentrations of TDP‐43 were significantly decreased in LATE‐NC (+), as measured by the Cusabio kit (F). EV depleted plasma concentrations of TDP‐43 were not significantly different between LATE‐NC (+) (n = 22) and LATE‐NC (–) subjects (n = 42).