TABLE 1.
Patient demographics for the 64 patients’ blood samples that were included in the study. EV preparations were enriched against neuronal (NDEVs), astrocyte (ADEVs), and microglial sources (MDEVs). EV cargo protein, TDP‐43 was measured by human ELISA. Categorical variables are summarized using counts and percentages (%) with continuous variables summarized using means and standard deviation (SD). Two‐tailed t‐test; LATE‐NC (–) versus LATE‐ NC(+)
| Patient demographic data (n = 64) | ||||
|---|---|---|---|---|
| Characteristic, P value |
LATE – NC (–) (N = 42) |
LATE – NC (+) (N = 22) |
Combined (N = 64) |
|
| Age of death, mean (SD) P = .936 | 80 (9.6) | 84 (9.7) | 81 (9.8) | |
| MMSE, mean (SD) P < .05 | 22 (8.0) | 17 (11) | 21 (9.2) | |
| Yrs of Ed mean (SD), P = .281 | 16 (3.6) | 18 (2.9) | 17 (3.4) | |
| Last Clinical Index | Control | 13 (31%) | 3 (13.6%) | 16 (25%) |
| MCI or Impaired | 9 (21.4%) | 3 (13.6%) | 12 (18.75%) | |
| Demented (AD) | 20 (47.6%) | 16 (72.7%) | 36 (56.25%) | |
| Sex | Female | 21 (50.0%) | 9 (40.9%) | 30 (46.9%) |
| Male | 21 (50.0%) | 13 (59.1%) | 34 (53.1%) | |
| APOEε4 | Negative | 24 (57.1%) | 10 (45.5%) | 35 (54.7%) |
| Positive | 17 (40.5%) | 11 (50%) | 28 (43.8%) | |
| (Missing) | 1 (2.4%) | 1 (4.5%) | 2 (1.5%) | |
| Race | White | 40 (95.2%) | 21 (95.5%) | 61 (95.3%) |
|
Black or African American |
2 (4.8%) | 1 (4.5%) | 3 (4.7%) | |
| Hispanics | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |
| Asian | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |
| American Indian or Alaska Native | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | |