Table 4.
Univariate and multivariate logistic regression analyses of factors affecting in-hospital mortality
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| RR (95% CI) | P value | RR (95% CI) | P value | |
| Age (per increase of 5-year) | 1.47 (1.11–1.96) | 0.008 | 0.95 (0.60–1.51) | 0.836 |
| BMI (per increase of 1 point) | 0.94 (0.84–1.05) | 0.243 | 0.90 (0.76–1.06) | 0.201 |
| Sex (female vs. male) | 0.60 (0.23–1.61) | 0.312 | 0.35 (0.05–2.19) | 0.259 |
| Smoking status (never smoker vs. current/ever smoker) | 1.23 (0.41–3.76) | 0.713 | 3.09 (0.40–23.70) | 0.277 |
| Exacerbations during preceding year (yes vs. no) | 2.50 (1.03–6.07) | 0.044 | 2.93 (0.74–11.59) | 0.127 |
| GOLD stage (per increase to next stage) | 0.87 (0.52–1.45) | 0.590 | ||
| CHF (yes vs. no) | 6.07 (2.41–15.29) | < 0.001 | 4.36 (1.07–17.85) | 0.040 |
| RD (yes vs. no) | 0.85 (0.36–1.99) | 0.701 | 0.32 (0.09–1.13) | 0.076 |
| Bronchiectasis (yes vs. no) | 0.47 (0.16–1.43) | 0.186 | ||
| Diabetes (yes vs. no) | 0.84 (0.19–3.78) | 0.825 | ||
| Hypertension (yes vs. no) | 1.06 (0.45–2.50) | 0.893 | ||
| CHD (yes vs. no) | 1.54 (0.63–3.79) | 0.343 | ||
| Neutrophil count(per increase of 1 × 109/L) | 1.16 (1.08–1.24) | < 0.001 | 1.15 (1.02–1.30) | 0.020 |
| Lymphocyte count(per increase of 1 × 109/L) | 0.24 (0.09–0.59) | 0.002 | 0.36 (0.09–1.47) | 0.154 |
| PH | ||||
| (PH < 7.35 vs. 7.35 ≤ PH ≤ 7.45) | 5.08 (1.78–14.48) | 0.002 | 8.87 (1.62–48.55) | 0.012 |
| (PH > 7.45 vs. 7.35 ≤ PH ≤ 7.45) | 7.31 (2.51–21.32) | < 0.001 | 4.04 (0.87–18.81) | 0.075 |
| PaO2 (≥ 60 vs. < 60 mmHg) | 4.56 (1.51–13.77) | 0.007 | 4.86 (0.89–26.67) | 0.069 |
| PaCO2 (≥ 50 vs. < 50 mmHg) | 1.88 (0.74–4.77) | 0.187 | ||
| BUN/ALB ratio (≥ 0.249 vs. < 0.249) | 22.39 (7.88–63.62) | < 0.001 | 15.08 (3.80–59.78) | < 0.001 |