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. 2022 Dec 15;19:101. doi: 10.1186/s12987-022-00382-4

Fig. 12.

Fig. 12

Non-invasive MRI of the blood–cerebrospinal fluid barrier (BCSFB) function. a Diagram for the principle underlying arterial spin labeling. The arterial blood water of the brain feeding arteries is spin-labelled, and the signal is measured from labelled blood water that has been transported to the CSF. b Above—traditional arterial spin labeling (ASL) signal probes blood–brain barrier (BBB) function and the novel BCSFB-ASL signal, below—ASL images from a single mouse.

Modified from Evans et al. [130]