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Illustration of the set-up for the CSF withdrawal in human. The patient is placed in the lateral recumbent position and a lumbar needle is inserted into the subarachnoid space. A certain volume of CSF is withdrawn through the needle, and ICP is monitored through a three-way stopcock. ICP will decrease during the acute CSF withdrawal, and the time required for the return of CSF pressure to its initial pressure is recorded to calculate the CSF production rate
