Fig. 5.

Both mouse sexes exhibit consistent visually-evoked innate fear behavior throughout life. A Experiment flow chart. B The escape probability of different mouse groups following looming stimuli. C–J Between-group comparisons of C the latency for mice to initiate flight behavior following looming stimuli onset, D the time taken to return to refuge following looming stimuli onset, E the mean return speed back to the refuge following looming stimuli onset, F the time spent in the refuge following looming stimuli onset, G the ratio of time spent in the center of the arena in the 5-min acclimation period, H the ratio of time spent in the refuge to time spent outside the refuge during the 5-min acclimation period, I the mean speed during the 5-min acclimation period, and J the initial location distance at stimuli onset to refuge following looming stimuli onset. (a) 3-week-old male mice vs. male mice of different age group (6 W, 12 W, 8 M, 12 M, and 20 M); (b) 3-week-old female mice vs. female mice of different age group (6 W, 12 W, 12 M, and 20 M). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. ^##p < 0.01; ^###p < 0.001; ^####p < 0.0001. Data are expressed as mean ± SEM