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. 2022 Nov 10;41(24):e112440. doi: 10.15252/embj.2022112440

Figure 3. Structural model of the IFT88/70/52/46 IFT‐B1 subcomplex.

Figure 3

  1. The AlphaFold predicted model of CrIFT88120–713/70/52/46188–319/81587–645/74583‐C.
  2. The predicted alignment error plot of the complex from A. The residue indexes are indicated on the X‐ and Y‐axis.
  3. The CrIFT88/70/52 cross‐linking network validates the interaction interface predicted by AlphaFold. The lime‐green dashed lines are showing cross‐linking pairs formed between IFT88 and IFT70. The orange dashed lines are showing the IFT88/52 cross‐links and the pink lines are showing the cross‐links between IFT52 and IFT70. K321 and K325 of IFT52 make multiple short‐range interactions with both IFT88 and IFT70 residues.
  4. The crystal structure of Chlamydomonas IFT881–437/70/52281–360 displayed as ribbon and the 2Fo ‐ Fc omit map (3sigma) as a yellow mesh (left panel). Surface representation of the structure is shown on right panel.
  5. The crystal structure of Chlamydomonas IFT70/52330–430/46165–319 displayed as ribbon and the 2Fo ‐ Fc omit map (3sigma) as a yellow mesh (left panel). Surface representation of the structure is shown on right panel.