Table 1. In Vitro Cytotoxic Activity of Tested Compounds against the HNSCC Cell Line.

The table presents the structure of the compounds (R₁ substitution), their respective percent cytotoxicity, and IC₅₀ values at two different time points of 24 and 48 h calculated after three independent experiments. Here, vinblastine was used as a positive control; ND* means the IC₅₀ value was not determined as the compound does not exert >50% cytotoxicity at the highest concentration (100 μM) and ND^# means the value was not determined due to the self-aggregation of compounds at high concentrations that leads to drop in cytotoxicity potential.