Table 3. Selected Proteins That Are Likely to be Involved in the Pharmacodynamics and Pharmacokinetics (Metabolism, Distribution, Excretion, and Absorption) of the Selected Antihypertensive Drugs^a.

drug class	pharmacodynamic biological targets	pharmacokinetic biological targets
		metabolism	distribution	excretion	absorption
thiazide and thiazide-like diuretics	solute carrier family 12 member 3 (NaCl symporter, NCC)	CYP3A4	albumin	solute carrier family 22 member 6 (OAT1)
		microsomal epoxide hydrolase 1	α1-acid glycoprotein 1
	solute carrier family 12 member 1 (Na–Cl–K symporter, NKCC)
	calcium-activated potassium channel subunit α 1 (BK channel, BK)
	carbonic anhydrase 1/2/4 (CA1/2/4)
calcium channel blockers	voltage-dependent L-type calcium channel subunit α1C (Cav1.2)	CYP3A4	albumin	P-glycoprotein 1 (P-gP)
		CYP3A5
		CYP2B6
		CYP1A2
	voltage-dependent T-type calcium channel subunit α1I (Cav3.3)	CYP2A6	α1-acid glycoprotein
	voltage-dependent L-type calcium channel subunit α1D (Cav3.3)
	voltage-dependent L-type calcium channel subunit β2 (Cav1.2b)
ACE-I	angiotensin-converting enzyme (ACE)		albumin	solute carrier organic anion transporter family member 1A2 (OATP1)	solute carrier family 15-member 1 (PEPT1)
	renin		α1-acid glycoprotein		solute carrier family 15-member 2 (PEPT2)
ARBs	type 1 angiotensin II receptor (AT1)	CYP2C9	albumin	solute carrier organic anion transporter family member 1B3 (OATP8)
		CYP3A4
		UDP-glucuronosyl transferase 1-1
		UDP-glucuronosyl transferase 1-3		solute carrier organic anion transporter family member 1B1 (OATP2)
		UDP-glucuronosyl transferase 1-10
		UDP-glucuronosyl transferase 2B7		canalicular multispecific organic anion transporter 1 (MRP2)
		UDP-glucuronosyl transferase 2B17		P-glycoprotein 1 (P-gp)

^aSee Appendix I, Table S2 for a total overview.