Table 7. Molecular Docking Results of Angiotensin-Converting Enzyme Inhibitors^a.

	pharmacodynamics		distribution		absorption		excretion
ligand	ACE	renin	albumin	α1GlycP1	PEPT1	PEPT2	OATP1
lisinopril (reference ligand)	0.66
ligand X (reference ligand)		0.04
bendroflumethiazide	0.07	0.13	0.12	0.22	0.11	0.87	0.31
chlorthalidone	0.47	0.10	0.17	0.67	0.45	0.46	0.40
indapamide	0.14	0.37	1.07	0.12	0.33	0.07	0.34
losartan	0.19	1.51		1.03	0.31	0.65	0.93
valsartan	0.31	3.53	1.41	0.44	0.31	0.23	0.76
nifedipine	0.83	0.98	4.02	2.27	1.55	2.15	4.90
amlodipine	1.44	1.50		4.14	4.46		7.79
ramipril	0.41	1.49	2.27	0.50	0.99	0.36	0.70
enalapril	1.17	2.14	0.41	0.99	4.53	0.56	3.45
lisinopril	1.43	1.69	0.89	1.84	2.67	1.72	4.62
mitraphylline	0.17	0.10	0.96	0.07	0.22	2.02	0.19
8-hydroxytricetin 7-glucuronide	0.06	0.26	0.08	1.12	0.12	0.05	0.15
oleanolic acid	0.13	0.08	0.04	0.06	0.01	0.50	0.09
verbascoside	0.18	0.41	0.11	1.42	0.15	3.29	0.01
rutin	0.10	0.35	0.09	0.34	0.56	0.05	0.08
corilagin	0.02	0.35	0.49	0.21	0.04	1.45	0.53
reserpine	2.00	0.49	1.80			2.98	0.21
vincamine	0.39	0.09	7.33	0.81	1.53	3.85	0.78
coreximine	0.68	4.82	1.74	2.22	1.03	0.31	1.31
kaempferol	1.28	4.83	0.49	0.78	1.56	1.01	2.48
quercitrin	0.20	0.54	1.62	0.28	0.43	0.78	0.45
apigenin	1.38	4.21	0.42	0.79	1.43	0.58	1.87
astragalin	0.23	0.96	0.41	1.33	0.63	4.70	0.82
aucubin	1.42	4.18	7.94	3.39	7.81	1.33
adenosine	6.69		9.99		9.67	3.79
caffeic acid			1.42				8.83
tryptophan	9.54	5.80		9.24
subaphyllin	8.70					9.54	4.59
estragole			5.85
α-linolenic acid		8.09		9.13		8.32

^aBinding affinities are presented as dissociation constants (K_d) in μM. Dissociation constants of reference ligands of corresponding proteins and selected antihypertensive drugs are also presented.