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. 2022 Dec 1;13:935949. doi: 10.3389/fimmu.2022.935949

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Copyright © 2022 Hassan, Eldershaw, Stephens, Kinsella, Craddock, Malladi, Zuo and Moss

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NK cells undergo long term expansion following short term CMV reactivation. The percentage and number of peripheral NK cells was measured at regular timepoints prior to, and following, an episode of CMV reactivation in patients after HSCT. Matched timepoint samples were obtained from patients without an episode of reactivation. Sample times are shown as week (W) or month (m). (A) Percentage of NK cells in patients with CMV reactivation. (B) Percentage of NK cells in patients without CMV reactivation. (C) Number of NK cells in patients with CMV reactivation. (D) Number of NK cells in patients without CMV reactivation. Patients were classified as undergoing an episode of CMV reactivation when viral load reached > 200 copies/ml. Grey line represents the percentage range of NK cells within healthy donors. (*p<0.05, **p<0.01, ***p<0.001; Wilcoxon sign rank test for matched time points).