Table 1.
Different Niosomal Formulations for Encapsulation of Letrozole (L1-L6)
| Formulation | Type of Surfactant | Lipida/Drug (Mol Ratio) | HLBb | Transition Temperature, Tc (°C) | Drug Concentration (mg/mL) | Sonication Time (min) | Surfactant: Cholesterol: DCPc (Molar Ratio) |
|---|---|---|---|---|---|---|---|
| L1 | Span20 | 10 | 8.60 | 16 | 1 | 5 | 2:1:0.05 |
| L2 | Span60 | 10 | 4.70 | 53 | 1 | 5 | 2:1:0.05 |
| L3 | Span80 | 10 | 4.30 | −12 | 1 | 5 | 2:1:0.05 |
| L4 | Span20 | 20 | 8.60 | 16 | 1 | 5 | 2:1:0.05 |
| L5 | Span60 | 20 | 4.70 | 53 | 1 | 5 | 2:1:0.05 |
| L6 | Span80 | 20 | 4.30 | −12 | 1 | 5 | 2:1:0.05 |
Notes: aLipid is the total amount of cholesterol, surfactant, and DCP. bHydrophilic-lipophilic balance. cDCP: Diacetyl phosphate.