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. 2022 Dec 15;5:1376. doi: 10.1038/s42003-022-04322-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Panels represent SARS-CoV-2 strains found in (a) Molnupiravir-treated, (b) Paxlovid-treated and (c) drug-naïve individuals across time points. Each time point is defined by one track and grouped according to patient. Tracks in black represent timepoints not available; striped tracks represent samples not sequenced as viral load was undetectable. SNPs are defined by different colors, shapes and size according to type of nucleotide substitution (red: G-A; orange: C-T; green: other), non-synonymus (circle) or synonymus mutations (triangle), and intra-patient prevalence, respectively. The outside track corresponds to SARS-CoV-2 genome architecture. Overlapping orfs are not reported and comprise: orf2b (coordinates 21744–21860) overlapping S; orf3b (coordinates 25814–25879), orf3c (coordinates 25457–25579), orf3d (coordinates 25524–25694) and orf3d-2 (coordinates 25596–25694) overlapping orf3a; orf9b (coordinates 28284–28574) and orf9c (coordinates 28734–28952) overlapping N.