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. 2022 Dec 15;132(24):e161408. doi: 10.1172/JCI161408

Figure 5. GS ablation enhances Glu-derived amino acids upon oncogene activation.

Figure 5

Seven-week-old Glulfl/fl Alb-Cre– (WT) and Glulfl/fl Alb-Cre+ (KO) male mice were injected with vehicle or c-Met/ΔN90-β-catenin/SB10 plasmids via SB-HTVI. Livers were harvested at the indicated time points. (A) Relative abundance of metabolites was determined by LC-MS. Volcano blots of differentially present metabolites between the KO and WT livers are shown. x axis: log2(fold change); y axis: –log10(P value). (B) Liver tissues were collected 2 weeks after oncogene injection. Absolute concentrations for the indicated amino acids were determined using spikes of respective standards. *P < 0.05 by 2-tailed t test in B.