TABLE 5.
The sensitivity, specificity, and AUC of the 12 verified hub genes in detecting renal involvement in SLE.
| Rank | Gene symbol | Sensitivity (%) | Specificity (%) | AUC (95% CI) |
Cut-off value |
| 1 | DEFA4 | 58 | 75 | 0.686 (0.598-0.775) | 8.063 |
| 2 | CTSG | 62.3 | 70.6 | 0.675 (0.585-0.766) | 6.103 |
| 3 | RETN | 65.2 | 70.6 | 0.697 (0.609-0.786) | 6.219 |
| 4 | CEACAM8 | 82.7 | 51.5 | 0.684 (0.595-0.773) | 5.418 |
| 5 | PRTN3 | 47.8 | 83.8 | 0.643 (0.563-0.722) | 3.623 |
| 6 | TOP2A | 43.5 | 85.3 | 0.634 (0.543-0.726) | 5.263 |
| 7 | LTF | 62.3 | 70.6 | 0.682 (0.592-0.772) | 6.846 |
| 8 | MPO | 71 | 64.7 | 0.686 (0.597-0.775) | 4.547 |
| 9 | ELANE | 63.8 | 75 | 0.692 (0.602-0.782) | 7.053 |
| 10 | MMP8 | 49.3 | 73.5 | 0.626 (0.544-0.709) | 3.666 |
| 11 | BIRC5 | 53.6 | 67.6 | 0.597 (0.508-0.685) | 3.476 |
| 12 | LCN2 | 65.2 | 72.1 | 0.738 (0.654-0.821) | 9.888 |
| Model | 91.3 | 52.9 | 0.775 (0.697-0.853) | −0.65 |
AUC, area under the curve; CI, confidence interval. Combination model: −10.9192 + 0.2482 * DEFA4 + −0.159 * CTSG + 0.2673 * RETN + −0.2245 * CEACAM8 + −0.5405 * PRTN3 + −0.3169 * LTF + 0.4004 * MPO + −0.1196 * ELANE + 1.1 * LCN2 + −0.1195 * MMP8 + 0.3778 * BIRC5 + 0.2318 * TOP2A.