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. 2022 Dec 13;15(1):2153409. doi: 10.1080/19420862.2022.2153409

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Structural modeling of the binding of full-length antibody to dimeric CTLA-4 on cell surface. (a-b) Structure of dimeric CTLA-4 (a) and the binding of B7-1 to dimeric CTLA-4 (b). The B7-1 is depicted in lemon while CTLA-4 in gray. (c-f) Structure of full-length JS007 (c), HL32 (d), ipilimumab (e) and tremelimumab (f) antibodies to dimeric CTLA-4. The heavy chain of antibody is presented as cartoon in blue, while the light chain is colored in salmon. The dimeric CTLA-4 is presented as surface and colored in gray.