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. 2022 Dec 15;17(12):e0279041. doi: 10.1371/journal.pone.0279041

Fig 7. Beta cell function is diminished in P HFHS.

Fig 7

Glucose stimulated insulin secretion (GSIS) is high at basal and blunted in response to glucose in P HFHS dams by mid pregnancy (Fig C). Insulin secretion in the basal and secreted state in Fig A-C and total insulin in Fig D-F at day 0 (Fig A and D), 13.5 (Fig B and E) and 17.5 (Fig C and F) of pregnancy. Day 0 n = 4 CD and 4 HFHS mice, day 13.5 n = 6 NP CD, 9 P CD, 9 NP HFHS mice, and 9 P HFHS, day 17.5 n = 8 NP CD, 9 P CD, 6 NP HFHS, and 15 P HFHS mice. Lines represent median values. * represents p<0.05.