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. 2022 Dec 15;12:21723. doi: 10.1038/s41598-022-26157-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The impact of H. perforatum, Echinacea and the H. perforatum-Echinacea mixture on SARS-CoV-2 infected-Vero E6 cells by anti-viral activity essays (A,B,C). The cell viability and CPE through SARS-CoV-2 infectious cycle, from 24 to 48 h post infection, were visualized by photographed images by the crystal violet assay (blue circles). The images were captured when the CPE started on the positive control at 24 h. The results were representatives of two independent experiments and performed in triplicate.