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. 2022 Dec 1;10:1025550. doi: 10.3389/fpubh.2022.1025550

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Copyright © 2022 He, Cao, Guo, He, Du, Zhang, Feng, Du, Zhang, Wang, Yan, Wang, Liu, Pan, Xin and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flow chart of serial testing of TST and C-TST according to IGRA results. (A) Stratified analysis according to baseline results of IGRA and TST (using cutoff value of 10 mm); (B) Stratified analysis according to baseline results of IGRA and C-TST. C-TST, Creation tuberculin skin test; IGRA, Interferon-gamma release assay; TST, Tuberculin skin test. TST conversion was defined as the average diameter of induration ≥ 10 mm for those with baseline survey < 5 mm, or increased ≥ 10 mm when the baseline survey result was between 5 and 10 mm. C-TST conversion was defined as the average diameter of induration and erythema increased from < 5mm at baseline survey to induration or erythema ≥ 5mm at follow-up survey. IGRA conversion was defined as the IFN-γ releasing level of TB antigen-Nil (TBAg-Nil) increased from < 0.35 IU/ml at baseline survey to ≥ 0.35 IU/ml at follow-up survey. Persistent positive was defined as both positive for baseline and follow-up surveys according to the baseline positivity cutoff value.