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. 2000 Jun;68(6):3129–3139. doi: 10.1128/iai.68.6.3129-3139.2000

FIG. 3.

FIG. 3

987P fimbria-specific total serum IgG, serum IgG1, and IgG2a (A) and serum IgA (B) responses. BALB/c mice were immunized orally with two doses (26-day interval) of serovar Typhimurium CS3263/pCS152(fasD) expressing fimbrial antigen in the periplasm (hatched bars) or serovar Typhimurium CS3263/pCS151 expressing 987P fimbriae on the surface (crossed bars). The sera collected before immunization (solid bars) were used as controls. Means and standard deviations of serum IgG and IgA titers of mice tested 6 to 8 weeks postimmunization are shown. Serum antibody titers elicited by serovar Typhimurium CS3263/pCS151 were significantly higher than the titers induced by serovar Typhimurium CS3263/pCS152 (∗, P < 0.05; ∗∗, P < 0.01; ∗∗∗, P < 0.001).