Fig. 1.

Figure highlighting the pathophysiology of MIS-A. SARS-CoV-2 infection is characterized by an inflammatory immune response comprising both the innate as well as the adaptive immune system leading to recovery in majority of cases. However, in a fraction of cases following recovery, there develops a dysregulated immune response leading to a hyperinflammatory phase characterized by macrophage activation which leads to activation of innate as well as adaptive immune system comprising B-cells and T-cells with the production of inflammatory cytokines as well as antibodies. These inflammatory cytokines lead to multisystem inflammatory response and development of MIS-A. The exact cause for the dysregulated immune response following recovery is not known however, has been speculated to be due to super antigens or persistent viral antigens or even autoantibodies. Figure created by Biorender.com. * Altered sensorium implies decreased consciousness, altered mental status, altered awareness or confusion.