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. 2022 Dec 15;10(12):E1517–E1525. doi: 10.1055/a-1949-7730

Table 3. Mean (SD) cyst volume in subjects receiving large surface area microparticle paclitaxel (LSAM-PTX).

Escalation Expansion Escalation and expansion
LSAM-PTX
6 mg/mL
(n = 3)		 LSAM-PTX
10 mg/mL
(n = 3)		 LSAM-PTX
15 mg/mL – Single Injection
(n = 5)		 LSAM-PTX
15 mg/mL – Two Injections
(n = 8)		 LSAM-PTX>
15 mg/mL
(n = 13)
Mean (SD) cyst volume based on all available diameters 1 , cm 3

  • Screening

 7.77 (3.28) 4.81 (5.11) 15.57 (9.46) 8.68 (5.80) 11.33 (7.85)

  • Week 12

 5.71 (3.89) 3.45 (2.19) 14.78 (12.78) 2 10.05 (8.98) 11.63 (10.06) 3

  • Week 24/end of study

 4.14 (3.92) 4.38 (0.52) 15.02 (12.14) 6.60 (8.14) 10.43 (10.56) 4
Mean (SD) cyst volume based on longest diameter, cm 3

  • Screening

 9.99 (1.68) 6.16 (4.81) 31.89 (20.04) 15.75 (10.36) 21.96 (16.23)

  • Week 12

 8.28 (4.06) 5.71 (0.94) 26.73 (19.73) 2 16.69 (16.47) 20.04 (17.41) 3

  • Week 24/end of study

 7.45 (7.10) 8.36 (2.74) 28.14 (16.21) 13.87 (16.02) 20.36 (17.00) 4
1

For cyst volume calculated from all available diameters, following rules are applied:

Volume = 1/6 × 3.14 × (d1 × d2 × d3), if 3 diameters were recorded.

Volume = 1/6 × 3.14 × (d1 × d2 2 ), if 2 diameters were recorded.

Volume = 1/6 × 3.14 × d1 3 , if 1 diameter was recorded.

2

n = 4.

3

n = 12.

4

n = 11.