Table 2.
Clinical trial design of therapeutic applications
| Clinical design | Population | Subject group | Control group | |
|---|---|---|---|---|
| reSET | Open-label, randomized | 507 Patients | Web-based reSET and reduced treatment as usual | Treatment as usual |
| reSET-O | Open-label, randomized | 170 Patients | Web-based reSET-O and treatment as usual | Treatment as usual |
| Somryst | Open-label, randomized | 1149 Patients | Somryst | Digital control: Health watch contained health and lifestyle web program without specific mental health or sleep-related content. |
| EndeavorRx | Double-blind, randomized | 348 Patients | EndeavorRx | Sham control: the sham app without effective algorithms. |
| NightWare | Double-blind, randomized | 70 Patients | NightWare | Sham control: the sham app consists of the same components as NightWare, but never intervenes during the night. |
| Parallel | Open-label, randomized | 558 Patients | Web-based parallel with minimal therapist support and treatment as usual | Treatment as usual |
| Therapist-delivered cognitive behavioral therapy via telephone and treatment as usual | ||||
| The CureApp smoking cessation system | Open-label, randomized | 584 Patients | The CureApp smoking cessation system | Sham control: a sham app without specific mental intervention and mobile CO checker |