TABLE 1.
Basic information of patients for the pharmacokinetics analysis in this study.
| n | Mean ± SD | Median (range) | |
|---|---|---|---|
| Patients | 84 | — | — |
| Sex (male: female) | 64:20 | — | — |
| Age (year) | — | 9.62 ± 2.73 | 9.17 (4.83–17.33) |
| Body weight (kg) | — | 40.25 ± 16.76 | 36.00 (17.90–100.00) |
| Height (cm) | — | 141.92 ± 15.85 | 142.00 (108.00–176.00) |
| Body surface area (m2) | — | 1.24 ± 0.32 | 1.21 (0.73–2.21) |
| ALT (U/L) | — | 14.67 ± 7.81 | 13.00 (5.00–50.00) |
| AST (U/L) | — | 21.47 ± 4.60 | 21.00 (12.00–33.00) |
| DBIL (mol/L) | — | 3.84 ± 1.36 | 3.60 (1.90–8.40) |
| TBIL (μmol/L) | — | 9.39 ± 3.92 | 8.65 (3.00–23.70) |
| γ-GT (U/L) | — | 13.14 ± 4.99 | 12.00 (7.00–40.00) |
| GLB (g/L) | — | 23.22 ± 3.15 | 23.35 (15.40–30.00) |
| ALB (g/L) | — | 48.51 ± 2.39 | 48.25 (43.10–55.30) |
| CRE (μmol/L) | — | 43.77 ± 10.29 | 42.05 (28.00–91.70) |
| BUN (mmol/L) | — | 4.54 ± 0.99 | 4.59 (2.20–7.60) |
| Cys-C (mg/L) | — | 0.86 ± 0.11 | 0.86 (0.62–1.25) |
| eGFR (mL/min·1.73m2) | — | 121.72 ± 18.58 | 121.56 (66.49–162.39) |
| Concentration of ARI (ng/ml) | — | 137.11 ± 81.47 | 123.96 (11.31–346.55) |
| Concentration of DARI (ng/ml) | — | 50.83 ± 29.39 | 44.10 (15.19–162.40) |
| Number of combined medication cases | |||
| Tiapride | 26 | — | — |
| Clonidine | 41 | — | — |
| Methylphenidate | 1 | — | — |
| Topiramate | 3 | — | — |
| Trihexyphenidate | 1 | — | — |
| Inosine | 4 | — | — |
| Chinese traditional medicine | 10 | — | — |