TABLE 3.
Pharmacokinetic parameters and bootstap results of the final model.
| Parameter | Final model | Bootstrap analysis | ||
|---|---|---|---|---|
| Estimate | RSE (%) | Bootstrap median | Bootstrap 95%CI | |
| θka (h−1) | 1.06 (fixed) | — | 1.06 (fixed) | — |
| θVd/F (L) | 219.91 | 23.36 | 226.07 | 158.86–370.98 |
| θCL/F (L·h−1) | 3.06 | 11.92 | 2.99 | 2.37–4.05 |
| θVd(m)/Fm (L) | 423.78 | 43.01 | 431.19 | 44.47–1,097.35 |
| θCL(m)/Fm (L·h−1) | 8.86 | 5.56 | 8.87 | 7.90–9.78 |
| θ1 | 1.00 (fixed) | — | 1.00 (fixed) | — |
| θ2 | 0.64 | 21.86 | 0.62 | 0.37–0.89 |
| θNM | 0.00 (fixed) | — | 0.00 (fixed) | — |
| θIM | -0.23 | 25.32 | -0.23 | -0.42–0.03 |
| θUM | 0.21 | 35.09 | 0.21 | 0.01–0.53 |
| θ3 | 1.00 (fixed) | — | 1.00 (fixed) | — |
| θ4 | 0.75 (fixed) | — | 0.75 (fixed) | — |
| Inter-individual variation | ||||
| ω2 Vd/F | 79.99 | 39.38 | 73.52 | 12.81–134.22 |
| ω2 CL/F | 12.07 | 24.52 | 10.90 | 4.43–17.35 |
| ω2 CL(m)/Fm | 15.31 | 30.63 | 14.75 | 5.44–24.05 |
| Intra-individual variation | ||||
| σARI (%) | 35.45 | 9.34 | 36.10 | 25.72–43.17 |
| σDARI (%) | 35.37 | 7.17 | 34.66 | 29.38–39.44 |
θ1, exponent for WT as covariate for Vd/F; θ2, exponent for WT as covariate for CL/F; θ3, exponent for WT as covariate for Vd(m)/Fm; θ4, exponent for WT as covariate for CL(m)/Fm.