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. 2022 Dec 15;13:7756. doi: 10.1038/s41467-022-35474-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Experimental diagram. b, c Pain development evoked by capsaicin. c PWT: F_{(2, 36)} = 16.62, P < 0.001; n = 7 per group. d, e Example images (d) and quantification (e) of c-Fos-positive neuron after saline or capsaicin (Cap). F_{(3, 16)} = 20.09, P < 0.0001; n = 5 per group. f, g Pain development after CFA injection. PWT: F_{(3, 44)} = 29.31, P < 0.001; PWL: F_{(3, 44)} = 17.67, P < 0.0001; n ≥ 6 per group. h, i Example images (h) and quantification (i) of c-Fos-positive neurons after saline or CFA. F_{(3, 16)} = 42.17, P < 0.0001; n = 5 per group. j, k Pain development after SNI. k PWT: F_{(5, 78)} = 21.23, P < 0.0001; PWL: F_{(5, 78)} = 6.12, P < 0.0001; n ≥ 7 per group. l, m Example images (l) and quantification (m) of c-Fos-positive neurons in week 2 after sham or SNI (F_{(3, 16)} = 37.97, P < 0.0001; n = 5 per group). n–q Example images (n, p) and quantification (o, q) of c-Fos-positive neurons after sham or SNI on the contralateral side (n ≥ 4 per group). o t = 11.56, P < 0.0001; q t = 10.94, P < 0.0001. r–u Example traces (r), evoked firing (s), resting membrane potential (V_m) (t) and input resistance (R_input) (u) in contralateral STN neurons in week 2 after sham or SNI. s F(_{1, 214}) = 128.9, P < 0.0001, n = 4 per group. t t = 1.21, P = 0.26, n = 5 per group. u t = 0.96, P = 0.37. n = 5 per group. **P < 0.01; Two-way ANOVA with Tukey’s post-hoc analysis for (c, g, k and s); One-way ANOVA with Tukey’s post-hoc analysis for (e, i and m); Two-tailed unpaired t test for (o, q, t, and u). Data are presented as mean ± SEM. Scale bars: 100 µm.