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. 2022 Dec 15;13:7756. doi: 10.1038/s41467-022-35474-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Timeline of experimental setup. b, c Example images of ChR2 (b) and NpHR (c) expressions in the STN. d–g Effect of activation or inhibition of the STN–LPB projection on pain thresholds (n = 8 per group). d F_{(1, 28)} = 20.8, P < 0.0001; e F_{(1, 28)} = 1.19, P = 0.28; f F_{(1, 28)} = 0.57, P = 0.46; g F_{(1, 28)} = 0.51, P = 0.48. h, i Effect of silencing of the STN–LPB projection on nocifensive behavior induced by capsaicin injection into hind paws (n = 8 per group). h Left, F_{(1, 14)} = 5.35, P = 0.03; Right, F_{(1, 14)} = 7.88, P = 0.01. i Left, F_{(1, 14)} = 0.88, P = 0.36; Right, F_{(1, 14)} = 0.18, P = 0.68. j, k Effect of silencing of the STN–LPB projection on PWT induced by Cap injection into hind legs (n = 8 per group). j Left, F_{(1, 14)} = 23.6, P = 0.0003; Right, F_{(1, 14)} = 29.3, P < 0.0001. k Left: F_{(1, 14)} = 0.15, P = 0.70; Right, F_{(1, 14)} = 0.11, P = 0.75. l, m Effect of silencing of the STN–LPB projection on pain threshold in CFA mice (n = 8 per group). l Left, F_{(2, 28)} = 17.47, P < 0.0001; Right, F_{(2, 28)} = 20.2, P < 0.0001. m Left, F_{(2, 28)} = 0.17, P = 0.84; Right, F_{(2, 28)} = 2.37, P = 0.11. n Effect of silencing of the STN–LPB projection on pain thresholds 2 weeks after SNI. Left, F_{(2, 36)} = 50.73, P < 0.0001; Right, F_{(2, 36)} = 43.08, P < 0.0001; n = 10 per group. o–q Silencing of the STN–LPB projection induced CPP (n = 10 per group). p F_{(1, 18)} = 9.69, P = 0.006; q F_{(1, 18)} = 0.15, P = 0.7. Gray and yellow triangles in panel (o) represent no light and yellow light presented in the chamber during the conditioning session, respectively. **P < 0.01; Two-way ANOVA with Tukey’s post-hoc analysis for (d–n, p, and q). Data are presented as mean ± SEM. Scale bars: 100 μm.