Table 4.
Study populations and case ascertainment methods.
| Study (Location) | HAAS (Hawaii, USA) | KPNC (California, USA) | REP (Minnesota, USA) | Ontario Health Care (Ontario, Canada) | Medicare program (USA) |
|---|---|---|---|---|---|
| Study population | Longitudinal Honolulu Heart Program cohort study participants: 8006 Japanese American men born between 1900 and 1919. Study cohort was assembled in Honolulu in 1965. Surveillance through 2011. | Participating members of a closed, integrated health care delivery system, Kaiser Permanente North California. | Residents of Olmsted County, Minnesota, USA | Residents of Ontario Canada, receiving health care from the provincial government. | Residents of the United States ages 65 and above, receiving health care from the federal government |
| Study data components, sources for PD case ascertainment | Longitudinal cohort data (screening and confirmatory examinations), medical records. | Medical records for care delivered in the inpatient outpatient settings, plus prescribing data. | Electronic medical records | Health care administrative claims for care delivered in the inpatient and outpatient settings, prescription claims. | Health care administrative claims for care delivered in the inpatient and outpatient settings, prescription claims. |
| PD diagnostic criteria | Movement disorders neurologist consensus diagnosis, made after review of research and medical records, qualifying research clinical examination.1 | Algorithm that includes multiple PD diagnoses by a qualified physician, PD motor symptom medication. | Neurologist diagnosis, made after medical records review of potential cases identified via electronic screen2 | Algorithm that includes two outpatient or one inpatient PD diagnosis (ICD-9 code = 332 or ICD-10 code = G20), made by a physician or advanced practice provider, plus at least one antiparkinson medication prescription fill.a | Algorithm that includes two outpatient or one inpatient PD diagnosis (ICD-9 code = 332 or ICD-10 code = G20), made by a physician or advanced practice provider, plus at least one antiparkinson medication prescription fill. |
PD Parkinson Disease, ICD International Classification of Disease, HAAS Honolulu Asia Aging study, KPNC Kaiser Permanente Northern California, REP Rochester Epidemiology Project
aMedication dispensing data available only for those over age 65.