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. 2022 Dec 15;13:7766. doi: 10.1038/s41467-022-35303-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Analysis of caudal elements in wildtype and TCre^ERT2;Nr6a1^flx/flx and Nr6a1^flx/flx embryos (n = 13 and n = 8 biologically independent samples, respectively) revealed no difference in vertebrae morphology or number. B Whole mount in situ hybridisation for the somite marker Uncx4.1 revealed a rostral shift in hindlimb positioning in TCre^ERT2;Nr6a1^flx/flx embryos compared to control, somite number is marked in the right panel. Additionally, somite morphology was specifically disrupted in the future thoraco-lumbar region of TCre^ERT2;Nr6a1^flx/flx embryos, returning to normal immediately after the hindlimb bud. Co-expression analysis of Gdf11 (red arrows) revealed no change in expression in the tailbud between genotypes. Consistent expression patterns were observed in 2 biologically independent samples/genotype.